姓名：赵玉芬
性别：女
职称：教授
学科方向：
生命有机化学，有机磷化学，生命起源，药物化学，化学生物学
准备让学生参与的课题：
新型布雷菲德菌素A(Brefeldin A)类肿瘤先导化合物的设计、合成及筛选
教师简介
1971 台湾清华大学化学学士
1975 美国纽约州立大学石溪分校化学博士
导师：Fausto Ramirez教授
1976-1977 美国纽约州立大学石溪分校化学系博士后
从事ATP磷化学研究导师：Fausto Ramirez教授
1977-1979 在美国纽约大学化学系Robert Shapiro教授小组
从事核酸化学研究（NIH Fellowship）
1979-1988 中国科学院化学研究所副教授、教授
1988- 至今清华大学化学系教授
1993-2004 清华大学生命有机磷教育部开放实验室（2002年10月，更名为“生命有机磷化学及化学生物学教育部重点实验室”）主任
1994-2004 清华大学生命科学与工程研究院副院长
2000-至今 厦门大学化学化工学院教授
2006-至今 厦门大学医学院药学系主任
研究成果
生命起源：
发现了磷酰氨基酸能同时生成核酸及蛋白，又能生成LB-膜及脂质体。因此，它是生命进化的最小系统。
蛋白及DNA的切割剂：
发现了丝组二肽是世界上最小的能切割蛋白及核酸的肽。
药物化学：
采用全新的合成路线合成出二肽药物——丙氨酰谷氨酰胺（中国专利号：ZL 02123369.1，美国专利号：US 7163917 B2，PCT/CN03/00417，WO 03/106481A1）；分别于2004年10月22日及26日拿到了原料药及制剂的两个生产证书（原料药新药证书编号：证字H20041038，国药准字：H20041518）。
N-磷酰氨基酸自催化作用：
N-磷酰氨基酸可以自身组装成多肽，并将核苷磷酰化为核苷酸。因此，N-磷酰氨基酸可以在一锅反应中同时生成肽库；核酸库，及肽－核酸复合库。
组合化学与肽库：
以磷化合物为肽合成的缩和试剂，建立均肽和杂肽肽库以及它们与生理活性有机小分子形成的肽缀合物库，发展了新的肽库构建方法。
生物质谱学：
利用电喷雾质谱技术研究了一系列磷酰化小肽的裂解及重排规律，进行了生物大分子和有机小分子的弱相互作用研究以及蛋白的序列分析等。
代表性作品：
1. Rao HH, Fu H, Jiang YY, and Zhao YF, Easy Copper-Catalyzed Synthesis of Primary Aromatic Amines by Coupling Aromatic Boronic Acids with Aqueous Ammonia at Room Temperature, Angew. Chem. Int. Ed., 2009, 48, 1114-1116.
2. Gao YX, Wang G, Chen L, Xu PX, Zhao,YF , Zhou YB and Han LB, Copper-catalyzed aerobic oxidative coupling of terminal alkynes with H-phosphonates leading to alkynylphosphonates,J. AM. CHEM. SOC. 2009, 131, 7956–7957.
3. Ni F, Sun ST, Huang C, Zhao YF. N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis. Green Chem., 2009, 11, 569–573.
4. Ni F, Gao X, Zhao ZX, Huang C, and Zhao YF, On the Electrophilicity of cyclic acylphosphoramidates (CAPAs) postulated as intermediates,Eur. J. Org. Chem. 2009, 3026–3035.
5. Hou JB, Zhang H, Guo JN, Liu Y, Xu PX, Zhao YF and G. Michael Blackburn, Chirality at phosphorus in pentacoordinate spirophosphoranes: stereochemistry by X-ray structure and spectroscopic analysis, Org. Biomol. Chem., 2009, 7, 3020–3023.
6. Hou JB, Tang G, Guo JN, Liu Y, Zhang H, Zhao YF, Stereochemistry of chiral pentacoordinate spirophosphoranes correlated with solid-state circular dichroism and 1H NMR spectroscopy, Tetrahedron: Asymmetry, 2009, 20:1301–1307.
7. Gao X, Liu Y, Xu PX, Zhao YF. Alpha-amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate. Amino Acids. 2008, 34, 47-53.
8. Ma Y, Chen X, Sun M, Wan R, Zhu CJ, Li YM, Zhao YF. DNA cleavage function of seryl-histidine dipeptide and its application. Amino Acids. 2008, 35, 251-256.
9. Tang G, Ji T, Hu AF, Zhao YF. Novel N, S phenacyl protecting group and its application for peptide synthesis. Synthesis Letter. 2008, 12, 1907-1909.
10. Liu Y, Jin L, Hou JB, Xu PX, Zhao YF. Variation in proton affinity of the guanidine group between free and blocked arginine.Amino Acids. 2007, 33(1), 145-150.
11. Qiang LM, Cao SX, Mao XJ, Guo YC, Liao XC, Zhao YF. Electrospray ionization tandem mass spectrometry differentiation of N-phosphoryl-α-,β- andγ-amino acids. International Journal of Mass Spectrometry. 2007, 266, 42-49.
12. Fang H, Fang MJ, Liu XX, Zhao YF. Syntheses, characterizations, and crystal structures of phosphonopeptides. Heteroatom Chemistry, 2007, 18 (1), 9-15.
13. Niu MY, Cao SX, Ye Y, Zhang Z, Zhao YF. Amino-catalyzed fragmentation characteristics of polyamides containing N-methylpyrrole and N-methylimidazole by electrospray negative ionization mass spectrometry. Rapid Communications in Mass Spectrometr. 2006, 20, 1077-1081.
14. Ni F, Li W, Li Y, Zhao YF. Analysis of the phosphoryl transfer mechanism of c-amp dependent protein kinase (pka) by penta-coodinate phosphoric transition state theory. Current Protein & Peptide Science.2005, 6 (5), 437-442.
15. Fang MJ, Fang H, Huang YJ, Zhao YF. Mycoediketopiperazine, a novel fungal metabolite form a popularia sp. Tetrahedron Letters. 2005, 46, 2147–2148.
16. Zeng Q, Yin Q, Zhao YF. The study on the interaction between seryl-histidine dipeptide and proteins by circular dichroism and molecular modeling. Bioorganic & Medicinal Chemistry, 2005, 13, 2679.
17. Zhou GJ, Liu Z, Wang TJ, Xu PX, Tang G, Ye Y, Zhao YF, Electrospray ionization mass spectrometry study on dipeptide 4-chlorobutyl ester produced from refluxing of amino acid with phosphoryl chloride in tetrahydrofuran, Journal of Mass Spectrometry, 2005, 40 (10): 1382-1386 .
18. Chen XL, Qu LB, Zhang T, Zhao YF. The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy. Analytical Chemistry. 2004, 76, 211-217.
19. Chen ZZ, Chen SB, Chen Y, Li YM, Chen J, Zhao YF, Negative-ion electrospray ionization tandem mass spectrometry of n-phosphoryl amino acids and dipeptides. Rapid Communications in Mass Spectrometry, 2002, 16, 1-7.
20. Fu H, Li ZL, Zhao YF. Tu GZ., Oligomerization of N,O-bis(trimethylsilyl)-α-amino acids into peptides mediated by O-phenylene phosphorochloridate. Journal of the American Chemical Society, 1999, 121, 291-295.
电子邮件：
yfzhao@xmu.edu.cn
通讯地址:
厦门大学化学生物学系，361005
电话: 0952-2185610