姓名：张晓东
性别：男
职称：教授
学科方向：生物医药
准备让学生参与的课题：
1. 乙型肝炎病毒X蛋白（HBx）抗体药物
2. 乙型肝炎病毒X蛋白（HBx）多肽药物
教师简介
张晓东，男，1996年7月毕业于中国第四军医大学病理学专业，获医学博士学位（M.D., Ph.D.）。现任南开大学生命科学学院教授，博士生导师，分子生物学研究所肿瘤研究室主任，中国抗癌协会肿瘤标志物专业委员会常委，天津市抗癌协会理事。先后留学英国、德国和日本。目前主持国家“973计划” 1项（课题组长），参加国家“973计划”1项（骨干）。主持国家自然科学基金（2项，已结题））和天津市科技发展计划科技攻关重点项目（4项）等科研项目。获得国家发明专利2项，申请国家发明专利11项。在国际SCI学术刊物上共发表论文30余篇。获得国家科技进步二等奖1项、省部级科技进步一等奖1项、二等奖2项等多项科研成果。
于2005年8月创建天津托普泰克生物科技有限公司，目前公司承担“十一五”863计划“疫苗与抗体工程”重大项目“抗心脑血管凝血，抗炎及抗病毒感染单抗”（项目编号：2006AA02A247）的子课题四“乙型肝炎病毒X蛋白（HBx）抗体药物”。天津市科技支撑计划重点项目“乙型肝炎病毒X蛋白（HBx）多肽药物”（项目编号：09ZCKSH08400）。
代表性作品：（*通讯作者）
1. Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD*. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. In press
2. Wang Q, Zhang WY, Liu Q, Zhang X, Na L, Ye LH*, Zhang XD*. A mutant of hepatitis B virus X protein (HBxΔ127) promotes cell growth via a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. Neoplasia, in press
3. Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV. J Biomed Biotechnol doi:10.1155/2009/289068
4. Zhang WY, Cai N, Ye LH, Zhang XD*. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sinica. 2009; 30(8):1153-61.
5. Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH*, Zhang XD*. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica,2009; 30(4):424-434
6. You J,Mi D, Zhou X,Qiao L, Xu S, Zhang XD*, Ye LH*. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation and migration. Endocrinology，2009;150(4):1607-17.
7. Zhou X, Liu Y, You J, Zhang XD*, Ye LH*. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Letters 2008; 270:312-327.
8. Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD *. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters 2008;269(1):67-77.
9. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang XD*. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells. Cell Res 2008;18:500-507
10. Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang XD*. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology, 2008;51:50-58
11. Qin X, Zhang H, Zhou X, Zhang H, Zhang XD*, Ye LH*. Proliferation and migration mediated by Dkk-1/Wnt/-catenin cascade in a model of hepatocellular carcinoma (HCC) cells. Translational Res 2007;150(5): 281-294
12. Zhang XD*, Zhang H, Ye LH. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab. Clin. Med. 2006;.147(2):58-66
13. Zhang XD*, Dong N, Zhang H, You J, Wang H and Ye LH. Effects of hepatitis B virus X protein on hTERT expression and activity in hepatoma cells. J Lab. Clin. Med. 2005; 145(2):98-104
14. Zhang XD*, Dong N, Yin L, Cai N, Ma H, Zhang H, You J, Wang H, He R and Ye LH. Hepatitis B virus X protein up-regulates survivin expression in hepatoma tissues. J Med. Virol 2005; 77:374-381
15. Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T and Naito M. Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nature Cell Biol, 2004; 6(9): 849-860.
电子邮件：zhangxd@nankai.edu.cn
通讯地址:天津市卫津路94号南开大学分子生物学研究所
电话: 022-23506830