张卫
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姓名:张卫
性别:男
职称:教授
学科方向:生物制药工程、海洋生物产品工程、生物过程工程

准备让学生参与的课题:
1 植物细胞培养生产小分子药物及现代中药组分;
2 海洋共附生放线菌的多样性、分离、培养及在医药、工业和农业中的应用;
3 植物及海洋微生物中生物活性天然产物的分离、纯化、结构鉴定及药物发现。

教师简介:

张卫研究员,中科院研究生院博士生导师,生物化学工程工学博士,现任澳大利亚Flinders大学医学院分子生物工程和生物产品实验室主任、副教授,Flinders大学“海洋生物加工和海洋生物产品研究中心”创建主任。天津大学、大连理工大学和厦门大学兼职教授,博士生导师。1999年“中国科学院百人计划”入选者。曾先后任日本东京大学博士后,澳大利亚阿德雷德大学,Flinders大学ARC研究员,英国剑桥大学研究员及“澳大利亚国家生物产品合作研究中心”植物细胞生物技术实验室主任,高级研究员。曾任多个国际会议主席,分会主席或组委,多次应邀在国际会议及大学作学术报告。曾担任七个国际杂志特辑编辑,现任三个国际杂志编委(Biotechnology Letters, Process Biochemistry, Biofuels),一个国际系列丛书主编。2006-2008年,担任参会代表超过2500人的13th International Symposium of Biotechnology and Exhibition 大会组委会共同主席和科学程序委员会委员。2008-2009年担任Chinese Journal of Biotechnology, Biotechnology Letters, Journal of Biotechnology, Biotechnology Advances, Enzyme and Microbial Technology, Pure and Applied Chemistry的客座编委;以及BIOMASS AND RESIDUES ASIA 2008的大会执行主席。张卫博士因其突出的学术成就,曾获国际国内多项科学奖包括两次"中国科学院院长奖学金优秀奖","日本文部省高技术研究奖学金","澳大利亚ARC Fellowship" 、"Flinders Technologies Research Fellowship","王宽诚科研奖",中国科学院"百人计划", “澳大利亚杰出青年科学家奖”(40岁以下) (Young Tall Poppy Science Awards) 和“南澳总理科学研究基金奖”。
张卫研究员的研究领域涵盖了植物细胞生物技术、海洋生生物技术、能源生物技术,主要研究工作重点是利用陆地和海洋中的动植物和微生物资源,开发生物工程技术生产医药、生物化学品和生物能源产品。从1999年到2008年,作为项目负责人,先后主持国际国内研究项目三十多项,已获国内外研究经费近6000万元。近十年间,共撰写论文100余篇,其中已发表论文92篇,接受待发表论文10余篇;第一作者论文15篇,通讯作者论文73篇。发表论文中,国际杂志44篇,国内杂志48篇。发表会议论文106篇,其中国际会议86篇,国内会议20篇。申请专利30件,其中国际专利4件,国内专利26件,第一发明人23件。出版编辑和译著3部。
张卫教授在天津国际生物医药联合研究院领导建立了植物细胞和海洋生物制药工程实验室,实验室一期建设面积为400平方米,有一流的科研软硬件环境,为技术研发与创新奠定了坚实基础。实验室以实现植物和海洋生物小分子药物和现代组分中药的质量稳定、标准化、可持续、经济和规模生产为目标,计划建立国际领先的植物细胞和海洋生物规模培养技术和生物医药产品的研发中心,进一步通过与国际、国内一流的研发机构、知名高校和著名医药公司的产学研合作,推动我国植物细胞生物技术、中药现代化和海洋生物制药研究和产业国际化。实验室高度重视国际合作,管理努力与国际接轨,已与多个国家的相关实验室建立了广泛的国际合作、人员交流与联合培养博士生计划。
欢迎有志于投身我国植物细胞培养生产小分子药物和组分中药产业、海洋生物技术发展的优秀研究生加盟!。

代表性作品:
1.Zhao Q.Y., Zhang W, Jin M.F., Yu X.J.,Deng M.C.Formulation of a basal medium for primary cell culture of the marine sponge Hymeniacidon perleve. Biotechnol. Prog., 21: 1008-1012, 2005.
2.Qu J.G., Zhang W., Yu X.J., Jin M.F. Instability of anthocyanin accumulation in Vitis vinifera L. var Gamay Freaux suspension cultures. Biotech. Bioprocess Eng., 10(2):155-161, 2005.
3.Zhang W., Franco C.M.M. Molecular bioprocessing: A new paradigm of bioprocess engineering. BIOforum Europe 1: 1-3, 2005.
4.Zhang L.H., Zhang W., Jin M.F., Zhang H.Y., Wang Y.J. Cloning and structure analysis of hydrogenase gene from Chlamydomonas reinhardtii SE. Process Biochem., 40(40): 2968-2972, 2005. 
5.Ran CQ, Yu XJ, Jin MF, Zhang W. Role of Carbonyl Cyanide M-Chlorophenylhydrazone in Enhancing Photobiological Hydrogen Production by Marine Green Alge Platymonas subcordiformis. Biotechnol. Prog. 22: 438-443, 2006.
6.Fu WT, Sun LM, Zhang XC, Zhang W. Potential of Marine Sponge Hymeniacidon perleve as a Bioremediator of Pathogenic Bacteria in Integrated Aquaculture Ecosystem. Biotechnol. Bioeng., 93: 1112~1122, 2006.
7.Zhang W., Cao XP, Yu XJ. Characterization of Silica Spicule Formation during Resuscitation & In Vitro Cell Culture of Hymeniacidon perleve. Develop. Biol. 295(1): 398-398, 2006.
8.Jin Y., Fotso S., Zheng YT, Sevvana M., Laatsch H.,  Zhang W. Halichondria sulfonic acid, a new HIV inhibitory guanidino-sulfonicacid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy. Nat Prod. Res. 20 (12): 1129-1135, 2006.
9.Zhang HT, Lee YK, Zhang W, Lee HK. Culturable Actinobacteria from the Marine Sponge Hymeniacidon perleve: Isolation and Phylogenetic Diversity by 16S rRNA gene-RFLP Analysis. Antonie van Leeuwenhoek Intern. J. Gen.  Mol. Microbiol., 90(2):159-169, 2006.
10.            Zhang HT, Zheng W, Huang JY, Luo HL, Jin Y, Zhang W, Liu ZH, Huang Y. Actinoalloteichus hymeniacidonis sp. nov., an actinomycete isolated from the marine sponge Hymeniacidon perleveInt J Syst Evol Microbiol 56: 2309-2312, 2006.
11.            Xiong CN, Li W, Liu H, Zhang W. et al. A normal mucin-binding lectin from the sponge Craniella australiensis. Comp. Biochem. Physiol., Part C, 143(1):9-16, 2006.
12.            Sun LM, Song YF, Qu Y, Yu XJ, Zhang W.Purification and in vitro Cultivation of the Archaeocytes (stem cells) of Marine Sponge Hymeniacidon perleve (Demospongiae). Cell Tissue Res., 328(1):223-237, 2007.
13.            Fu WT, Wu YC, Sun LM, Zhang W. Efficient Bioremediation of Total Organic Carbon(TOC)in Integrated Aquaculture System by Marine Sponge Hymeniacidon perleve. Biotechnol. Bioeng., 97(6): 1387-1397, 2007.
14.            Cao XP, Fu WT, Yu XJ, Zhang W. Dynamics of spicule evolution in marine sponge Hymeniacidon perlevis during in vitro cell culture and the seasonal development in field. Cell Tissue Res., 329(3): 595-608, 2007.
15.            Cao XP, Fu WT, Yu XJ, Zhang W.Comparison of Spiculogenesis in in Vitro ADCP-Primmorph and Explants Culture of Marine Sponge Hymeniacidon perleve with 3-TMOSPU Supplementation. Biotechnol. Prog., 23(3): 707-714, 2007.
16.            Li HY, Yu XJ, Jin Y, Zhang W, Liu YL. Development of an eco-friendly agar extraction technique from red seaweed Gracilaria lemaneiformis. Bioresour Technol. 99(8):3301-3305, 2008.
17.            Guo Z, Chen ZA, Zhang W, Yu XJ, Jin MF. Improved hydrogen photoproduction regulated by carbonylcyanide m -chlorophenylhrazone from marine green alga Platymonas subcordiformis grown in CO2-supplemented air bubble column bioreactor. Biotechnol. Lett., 30(5): 877-833, 2008
18.            Xin YJ, Huang JY, Deng MC, Zhang W. Culture-independent nested PCR method reveals high diversity of actinobacteria associated with the marine sponges Hymeniacidon perlevis and Sponge sp. Antonie van Leeuwenhoek, 94: 533-542, 2008
19.            Lee SK, Zhang W, Sanderson, BJS. Selective growth inhibition of human Leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction. J. Agri. Food Chem., (56): 7572-7577, 2008
20.            Zhang, W, Bai FW, Zhong JJ, Yang SL. Biotechnology for the Sustainability of Human Society - IBS 2008 Abstracts, 13th International Biotechnology Symposium and Exhibition, J. Biotechnol. 136 (Suppl 1): S1-S772, 2008

10件代表性专利(包括4项国际专利)
1.         Wei Zhang, Xiaoying Zhang, Quanyu Zhao, Liju Fang. A method for dissociation and re-aggregation of sponge cells for in vitro culture, CN 02133213.4(2002)
2.         Wei Zhang, Song Xu, Quan Yuan, Xingjun Yu, Meifang Jin.  A novel anti-tumor and anti-viral sulfated polyhydroxysterol isolated from marine sponge, Halichondria rugosa from South China Sea. CN 02144878.7 (2002)
3.         *Wei Zhang, Yingfu Guan, Xingjun Yu, Mwifang Jin, Manchun Deng, A method for two-stage photo-biological production of hydrogen by marine green microalgae, CN 03110981.0(2003)
4.         Wei Zhang, Xingju Yu, Meifang Jin, Zhaoan Chen, Hongbin Lu, Fei Yan, Chunqiu Ran. 2005. A method of hydrogen photo-production by marine green algae, coupled directly with Alkali Fuel Cells. CN 200510136770.X
5.         Wei Zhang, Mingbo Gao, Xinju Yu, Meifang Jin. 2007. A method of taxane hyper-production by Taxus cell culture. CN 200710011627.7
6.         Wei Zhang, Zhen Guo, Zhaoan Chen, et al. 2007. A method of promoting rapid growth of microalgae by CO2 supplementation for Photobiological H2 production.  CN200710010804.X
7.         *Wei Zhang, Chris Franco, 2003. Production Methods. Australian Provisional Patent Application No. 2003903909 
8.         *Wei Zhang, Chris Franco, 2004. Production of plant secondary metabolites. International Patent Application No. PCT/AU2004/000991 (2004)
9.         *Wei Zhang, Sun Liming, Jin Meifang, Yu Xingju. 2005. International Patent PCT/CN2005/001540: Isolation and cultivation of pluripotent archaeocytes of marine sponges
10.      Wei Zhang, Mingbo Gao, Xinju Yu, Meifang Jin. 2008 A method of taxane hyper-production by Taxus cell culture.  PCT/CN2008/070709

电子邮件:
weizhang@dicp.ac.cn;
Wei.Zhang@flinders.edu.au

通讯地址:
Associate Professor Wei Zhang
Founding Director, Flinders Centre for Marine Bioprocessing and Bioproducts (FCMB2)
Head, Molecular Bioprocessing and Bioproducts Engineering Laboratory
School of Medicine
Flinders University
Bedford Park, Adelaide, SA5042
Australia
Office: Room 4.21, Level 4 Health Sciences Bldg
Registry Rd, Flinders University

电话: +61-8-7221 8557; Fax: +61-8-7221 8555;
2009-12-22     


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