姓名：刘滨磊
性别：男
职称：教授
学科方向：
肿瘤免疫，病毒学，生物治疗
准备让学生参与的课题：
溶瘤性单纯疱疹病毒的溶瘤机制
溶瘤性单纯疱疹病毒与抗肿瘤免疫的关系
教师简介：刘滨磊，男，博士，中国医学科学院肿瘤研究所研究员。
83年获同济医科大学医学学士。89年获中国疾病预防控制中心医学硕士。于92年10月赴英国南安普敦大学分子微生物系做访问学者，后转读博士学位。96年获博士学位后继续在同一实验室作博士后研究工作。承担的研究课题包括：1）四种肠道病毒全基因组的序列分析； 2）四种肠道病毒全基因组的生物合成及基因功能的研究；3）性病疫苗的研究；4）淋球菌致病机理的研究。
2000年3月加盟英国BIOVEX生物技术公司，后任分子学首席科学家，负责肿瘤及传染病治疗性和预防性疫苗的研究工作。其中负责的减毒单纯疱疹病毒Ⅰ型肿瘤治疗注射液（OncoVEXGM-CSF）已进入临床Ⅲ期试验。
现受聘于中国医学科学院肿瘤医院/肿瘤研究所免疫室，研究员。主要从事溶瘤病毒的研究。
到目前为止，在国内外学术杂志上发表了20多篇论文。在国外的杂志上发表的文章十五篇。其中，在Journal of Virology发表三篇、Journal of Microbiology发表一篇、在基因治疗顶级杂志（Gene Therapy）发表一篇。
代表性作品：
产品研发：
减毒单纯疱疹病毒Ⅰ型肿瘤治疗注射液（OncoVEXGM-CSF）已进入临床Ⅲ期试验。
主要代表论文如下：
1．Liu, B-L., Clarke, I.N., Caul, E.O. and Lambden, P.R. Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses. Archives of Virology 140, 1345-1356 (1995).
2．Lambden, P.R., Liu, B-L., and Clarke, I.N.. A conserved sequence motif at the 5´ terminus of the Southampton virus genome is characteristic of the Caliciviridae. Virus Genes 10:2, 149-152 (1995).
3．Liu, B-L., Clarke, I.N., and Lambden, P.R. Polyprotein processing in Southampton Virus: Identification of 3C protease cleavage sites by in vitro mutagenesis J. Virol. 70, 2605-2610 (1996).
4．Noel, J.S., Liu, B.L., Humphrey, E.M., Rodrriguez, E.M., Lambden, P.R., Clarke, I.N., Dwyer, D.M., Ando. T. Monroe, S.S. and Glass, R.I. Human calicivirus associated with an outbreak of gastroenteritis in adults: A novel genetic variant in the Sapporo virus clade. J. Med. Virol. 52, 173 - 178 (1997).
5．Liu, B-L., Clarke, I.N., Caul, E.O. and Lambden, P.R. The genomic 5’ terminus of Manchester calicivirus. Virus Genes 15:1, 25-28 (1997)
6．Pelosi, E, Lambden, P.R., Caul, E.O., Liu, B-L., Dingle, K., Deng Y. and Clarke, I.N. The seroepidemiology of genogroup 1 and genogroup 2 Norwalk-like viruses in Italy. Journal of Medical Virology 58:1, 93-9 (1999).
7．Liu, B-L., Lambden, P.R.,. Gunther, H., Otto, P., Elschner, M and Clarke, I.N. Molecular characterisation of a bovine enteric calicivirus: relationship to the Norwalk-like viruses. J. Virology 73, 819-825 (1998).
8．Liu, B-L., Viljoen G.J., Clarke, I.N. and Lambden, P.R. Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E.coli. Journal of General virology 80, 291-296 (1999).
9．Christodoulides, M., Everson, J. S., Liu, B-L., Lambden, P.R., Thomas, E., Watt, P.J., and Heckels, J.E. Interaction of primary human endometrial cells with Nessaria gonorrhoea expressing green fluorescent protein. Molecular Microbiology. 35(1), 32-43 (2000).
10．Liu, B-L., Everson, J. S., Giannikopoulou, P., Vretou, E., Lambden, P.R., and Clarke, I.N. Molecular Characterisation of a bacteriophage from Chlamydia psittaci. J. Virology. 74, 3464-3469 (2000). 4
11．Everson JS, Garner SA, Fane B, Liu BL, Lambden PR, Clarke IN.Biological properties and cell tropism of Chp2, a bacteriophage of the obligate intracellular bacterium Chlamydophila abortus. J Bacteriol. 2002 May; 184(10):2748-54
12．Liu BL, Robinson M, Han ZQ, Branston RH, English C, Reay P, McGrath Y, Thomas SK, Thornton M, Bullock P, Love CA, Coffin RS，ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther. 2003 Feb;10(4):292-303.
13．Deng Y, Batten CA, Liu BL, Lambden PR, Elschner M, Gunther H, Otto P, Schnurch P, Eichhorn W, Herbst W, Clarke IN. Studies of epidemiology and seroprevalence of bovine noroviruses in Germany. J Clin Microbiol. 2003 Jun;41(6):2300-5
14．Simpson GR, Han ZQ, Liu BL, Wang YB, Campbell G and Coffin RS. Combination of a fusogenic glycoprotein prodrug activation, and oncolytic herpes simplex virus for enhanced local tumour control. Cancer Res. 2006 May 1;66 (9):4835-4842 16651439
15．Han ZQ, Assenberg M, Liu BL, Wang YB, Simpson G, Thomas S, Coffin RS. Development of a second-generation oncolytic Herpes simplex virus expressing TNF for cancer therapy. The Journal of Gene Medicine 2007 Jan; 9(2):99-106
电子邮件：
LIUBL1@yahoo.com
通讯地址:
北京朝阳区潘家园南里17号肿瘤研究所免疫室
电话:
010－87788415